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Friday, February 8, 2008

FDA Reviewing Proton-Pump-Inhibitor Safety.

The FDA is reviewing the condition of omeprazole (Prilosec, AstraZeneca) and esomeprazole (Nexium, AstraZeneca), proton-pump inhibitors used for the communicating of gastroesophageal flow disease (GERD) and ulcers, based on analyses from two clinical trials suggesting the drugs may gain cardiovascular risk, the way announced 24-hour interval .

But because of questions about the clinical-trial data and their mutual exclusiveness with a large total of other data screening no such increased risks, the "FDA does not believe that healthcare providers or patients should coin either their prescribing practices or their use of these products at this time," according to an "Early Communication" posted on the agency's website.

Sunday, February 3, 2008

Pearls for Recitation.

Although the FDA advises use of tacrolimus capsules when initiating therapy, intravenous therapy may be used if required and then converted to oral therapy within 2 or 3 days. The point oral dose should be given 8 to 12 hour followers discontinuation of the intravenous instillment.

Tacrolimus previously was approved for this reason by the European Credentials in April 2006.
The FDA has approved an expanded denotation for esomeprazole delayed-release capsules, allowing its use for the short-term handling of gastroesophageal pathology disease in patients aged 12 to 17 time period.New 320-mg/12.5-mg and 320-mg/25-mg strengths of valsartan/hydrochlorothiazide tablets have been approved for the tending of hypertension. In clinical studies, valsartan was associated with a dose-dependent drop-off in systolic and diastolic profligate pressing.A new reason for tacrolimus tablets and injections has been approved, allowing their use to prevent felony human activity in inwardness transplantation recipients. The recommended initial dose for oral therapy in this group is 0.075 mg/kg/day, administered every 12 hour in 2 divided doses and initiated no sooner than 6 period of time posttransplantation.